Causes of Depression

One of the most frustrating things about depression is that many times there is not just one cause. As with physical illness, many factors may contribute to the development of depression.

Genetics. Having a family history of depression doesn't mean you will definitely develop it as well. There is, however, evidence that depression runs in families, from one generation to the next.
Hormones and biochemicals. Research shows that the hormone system that responds to stress is overactive in some people with depression. There is also evidence that chemicals in the brain called neurotransmitters may not be working correctly in depressed persons. One of these chemicals may be serotonin.
Physical illness. People who have a physical illness, such as heart disease, cancer, or diabetes, may also become depressed. Without proper care, the depression may affect their willingness to seek and stay on treatment for other illnesses.
Anxiety. Often, people diagnosed with depression also have an anxiety disorder. In fact, it's estimated that as many as 90% of those with depression experience symptoms of anxiety. It's important for both to be identified to ensure proper and effective treatment.
Stress. Difficult life events such as a divorce or death of a loved one can cause a great deal of stress. Combined with other risk factors, this stress may make some people vulnerable to depression.
Self-esteem. For some people, factors such as a consistently pessimistic view of themselves and the world around them, being readily overwhelmed by stress, and a generally low sense of self-esteem can trigger depression.

For many people with depression, a combination of factors is responsible. The importance of any one factor over another is difficult to determine. But it's important to remember that, no matter what the cause, depression is a real, medical condition. With proper diagnosis and treatment, most cases of depression can be managed.

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